Abstract
LncRNA SRA1 plays important roles in several types of human diseases. The present study aimed to explore the role of SRA1 in cervical squamous cell carcinoma (CSCC). In the present study, we showed that plasma SRA1 was down-regulated in human papillomavirus (HPV)-negative CSCC patients but not in HPV-positive CSCC patients compared with healthy females. Down-regulated SRA1 distinguished HPV-negative CSCC patients from HPV-positive CSCC patients and healthy females. In HPV-negative CSCC patients, miR-9 was up-regulated and inversely correlated with SRA1. In HPV-negative CSCC cells, SRA1 overexpression caused the down-regulated miR-9, while miR-9 overexpression failed to affect SRA1. Moreover, SRA1 overexpression caused decreased, while miR-9 overexpression caused increased proliferation, migration and invasion rates of cancer cells. In addition, miR-9 overexpression attenuated the effects of SRA1 overexpression. Therefore, SRA1 is down-regulated in HPV-negative CSCC and regulates cancer cell behaviors possibly by down-regulating miR-9.
Highlights
In both developing and developed countries, cervical cancer is a common female malignancy and causes unacceptable high mortality rate [1]
We investigated the involvement of SRA1 in two types of cervical squamous cell carcinoma (CSCC)
We found that SRA1 was only down-regulated in Human papillomavirus (HPV)-negative CSCC and overexpression of SRA1 caused the inhibited cancer cell behaviors
Summary
In both developing and developed countries, cervical cancer is a common female malignancy and causes unacceptable high mortality rate [1]. Due to the low early diagnostic rate, only a small portion of cervical cancer patients are candidates for radical surgery [2]. Most patients with cervical cancer are diagnosed at advanced stages and overall 5-year survival rate is generally below 20% [3]. Human papillomavirus (HPV) infection is the major cause of cervical cancer. The popularization of HPV vaccines and early screening program has significantly reduced the incidence rate of cervical cancer [4]. Incidence of HPV-negative cervical cancer, which is a more malignant form of cervical cancer comparing with the HPV-positive subtype, showed an increasing trend in recent years [5,6]
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