Abstract
Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important biological processes. Although the number of known human lncRNAs has dramatically increased, they are poorly annotated, posing great challenges for better understanding their functional significance and elucidating their complex functioning molecular mechanisms. Here, we present LncBook (http://bigd.big.ac.cn/lncbook), a curated knowledgebase of human lncRNAs that features a comprehensive collection of human lncRNAs and systematic curation of lncRNAs by multi-omics data integration, functional annotation and disease association. In the present version, LncBook houses a large number of 270 044 lncRNAs and includes 1867 featured lncRNAs with 3762 lncRNA–function associations. It also integrates an abundance of multi-omics data from expression, methylation, genome variation and lncRNA–miRNA interaction. Also, LncBook incorporates 3772 experimentally validated lncRNA-disease associations and further identifies a total of 97 998 lncRNAs that are putatively disease-associated. Collectively, LncBook is dedicated to the integration and curation of human lncRNAs as well as their associated data and thus bears great promise to serve as a valuable knowledgebase for worldwide research communities.
Highlights
Long non-coding RNAs have a variety of functions in many important biological processes (1–5) and are closely associated with various diseases [6,7,8,9]
The human Long non-coding RNAs (lncRNAs) in LncBook were obtained from existing databases and published literature and from novel RNA assemblies based on RNA-seq data analysis (Figure 1)
LncBook is dedicated to the integration and curation of human lncRNAs as well as their associated data
Summary
Long non-coding RNAs (lncRNA) have a variety of functions in many important biological processes LncBook features a comprehensive collection of human lncRNAs and systematic curation of lncRNAs by multi-omics data integration, functional annotation and disease association (Table 1) It houses a larger number of human lncRNAs that are derived from existing databases and novel RNA assemblies based on RNA-seq data analysis. It includes community-contributed annotations from LncRNAWiki and expert-curated annotations curated from published literature, respectively. It integrates a variety of multi-omics data, including expression, methylation, variation, and interaction, conducts functional annotation and incorporates a collection of lncRNA-disease associations. LncBook organizes all relevant data in a structured manner, facilitating data browse/search with more enhanced efficiency and provides several useful tools for online analysis
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