Abstract
Previous studies have found that LMX1B rs10733682 polymorphism is associated with Body Mass Index (BMI) in European and American Indian adults. In this study, the association of rs10733682 polymorphism with obesity-related indicators, and its interaction with macronutrients and dietary patterns (DPs) were explored in Chinese children (n = 798). The rs10733682 polymorphism was genotyped by improved Multiple Ligase Detection Reaction (iMLDR). Four DPs were identified by factor analysis. The AA genotype had a higher incidence of overweight/obesity than GG+GA genotypes (P = 0.010) in girls (n = 398), but no difference in boys. The AA genotype in girls could interact with intake of energy, fat and carbohydrate, causing an increased triglyceride (TG), (P = 0.021, 0.003, 0.002, respectively), and also could interact with energy from protein, causing an elevated BMI (P = 0.023) and waist (P = 0.019). Girls inclining to the HED (high-energy density)-DP were associated with increased TG (P = 0.033), and girls inclining to the VEF (vegetables, eggs, and fishes based)-DP were associated with decreased total cholesterol (TC, P = 0.045) and decreased low density lipoprotein cholesterin (LDL, P = 0.016). The findings indicated that the AA genotype of rs10733682 and the HED-DP are potential risk factors of obesity in Chinese girls.
Highlights
The epidemic of overweightness and obesity has been observed from childhood, through adolescence to adulthood [1]
This study is the first to indicate the relationship between a novel Single nucleotide polymorphism (SNP) of LMX1B rs10733682 and general overweightness, obesity, and central obesity in Han Chinese girls
It was shown that the AA genotype can interact with an increased intake of total energy, fat, and carbohydrates, causing an increase of TG, and can interact with increased energy from proteins, causing an increase of Body Mass Index (BMI) and Waist circumference (WC)
Summary
The epidemic of overweightness and obesity has been observed from childhood, through adolescence to adulthood [1]. Childhood obesity is often accompanied with a risk of cardiovascular disease and metabolic syndrome, and associated with psychosocial problems, hypertension, dyslipidemia, type 2 diabetes, and even premature mortality in adulthood [2,3,4], as well as with an increased economic burden on individuals and society [5]. The incidence of childhood overweight and obesity in China continued to increase dramatically from 1991 to 2015 [6,7], which has become an urgent public health concern and requires unremitting research efforts to illuminate its causes and risk factors. From the perspective of traditional nutrition, environmental risk factors such as excessive energy intake, unbalanced dietary patterns, and physical inactivity are associated with the development of obesity. With the development of modern molecular nutrition, it has been gradually perceived that obesity arises from the interaction between
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