Abstract
Living in constant crisis--when stress management becomes the problem.
Highlights
Emergency services are supposed to just kick in during times of need, sort out the problem, and return to base
What happens if the emergency period never ends—is there a downside to living in a constant state of crisis? Our bodies have many surveillance systems; most of the time they stand idly by and only spring into action when the need arises, but we’re starting to appreciate that their inappropriate or long-term activation may not be a good thing
What happens if levels of misfolded proteins are always high? This occurs in Selected PLOS Biology research articles are accompanied by a synopsis written for a general audience to provide non-experts with insight into the significance of the published work
Summary
Emergency services are supposed to just kick in during times of need, sort out the problem, and return to base. When a crisis occurs and the cell detects unfolded or misfolded proteins, it activates the appropriate proteostatic stress pathway, resulting in the production of an army of chaperones that try to refold the casualties and minimise any harm done. Genetic diseases where the effect of the mutation disrupts the normal folding of the encoded protein.
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