Abstract
Introduction: Breast cancer is the secondary cause of cancer mortality in women. The majority of deaths are caused by metastasis. Isolated liver metastases are diagnosed in 2-12 % of patients. Liver resection is nowadays part of the multidisciplinary therapy in selected patients. The data about long-term survival are scarce. The aim of our study was to elucidate overall and recurrence- free survival of these patients. Method: We identified 16 patients who underwent liver resection because of isolated breast cancer metastasis over a period between 04/2006 and 12/2017 at the University Hospital of Salzburg. Results: All patients were women, the median age was 64 years (range 35- 76). The median time from diagnosis of breast cancer to metastasectomy was 37 months (range 1- 189). Liver metastasectomy was performed in all except one patient in whom left hemihepatectomie was performed. Six resections (37,5%) were done laparoscopically. Complications grade Clavien- Dindo IIIb and higher was in 1 (6,25%) patient and 30 days mortality was 0%. Recurrence was diagnosed in 10 (62,5%) patients with median recurrence-free survival of 15 months after liver resection (range 4- 39). Six patients (37,5%) were alive without recurrence, five of them over 5 years. The overall survival in the whole group was 45 months (range 7- 126). Conclusion: The resection of breast cancer liver metastasis promises in significant portion of selected patients long term survival. Further parameters need to be identified for personalized therapy.
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