Abstract
Liver Is T Cells' Ace in the Hole
Highlights
The intricacies of the adaptive immune system are a wonder to behold
antigen-presenting cells (APCs) carry the antigens to lymph nodes and other secondary lymphoid tissues (SLTs), where they are used as templates for mobilizing large numbers of lymphocytes—T cells and B cells—that have receptors designed to recognize that particular antigen
The team started by challenging mice that were engineered to lack any secondary lymphoid tissues with experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis that does not require a B cell response and so could be used to home in on T cell action
Summary
The intricacies of the adaptive immune system are a wonder to behold. Perceived invaders bearing surface characteristics, known as antigens, are picked up by evervigilant, widely circulating antigen-presenting cells (APCs). Is there a mystery participant in the immune response that might provide an alternate venue where lymphocytes and antigen-bearing APCs might interact and initiate the adaptive immune responses in the absence of SLTs?
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