Abstract
Purpose: Magnetic resonance imaging and spectroscopy provide a tool for fat quantitation for a wide range of liver conditions such as steatosis, non alcoholic fatty liver disease (NAFL), or non alcoholic steatohepatitis (NASH). Various methods are being used for fat quantitation, such as MR spectroscopy or 3-point Dixon. A practical method based on dual flip angle and in-phase and out-of-phase (IP-OP) echoes has been developed on 1.5T [1] and validated at 3T [2]. The method consisted of 3 distinct scans: a high flip angle (70°) and low flip angle (20°) in- and out-of-phase gradient echo sequences, followed by another T2 weighted dual-echo gradient echo scan for T2* measurement. Here we present an improvement of the method, where we acquired 6 echoes (3 in-phase/out-of-phase pairs) with dynamically varying flip angle, providing fat quantitation and T2* correction in a single breath hold scan.
Published Version
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