Abstract
A comparative study was made of the effects of prolonged propyl thiouracil or triiodothyronine treatment on rat liver alcohol and sorbitol dehydrogenase activities. The influence of voluntary alcohol consumption on these activities were also investigated. The liver-to-body weight ratio was increased by triiodothyronine treatment and also by voluntary alcohol consumption. Liver alcohol dehydrogenase activity was markedly increased by propyl thiouracil treatment and markedly decreased by triiodothyronine treatment. These changes in enzyme activity were statistically significant whether expressed in relation to liver wet weight, liver soluble protein content or body weight. Simultaneous voluntary alcohol consumption significantly inhibited the increase in alcohol dehydrogenase activity caused by propyl thiouracil treatment. Daily ethanol intake did not increase liver alcohol dehydrogenase activity in the animals. No marked changes were found in liver sorbitol dehydrogenase activity after propyl thiouracil or triiodothyronine treatment. The significance of the two liver enzymes in regulating the in vivo elimination rates of ethanol and sorbitol is discussed.
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