Abstract
• Chronic UC rats Gavaged with live or heat-killed cells were of 100% survival rate. • Live and heat-killed cells increased intestinal flora diversity of Chronic UC rats. • Live and heat-killed cells reduced intestinal permeability of Chronic UC rats. • Heat-killed cells were more effective against chronic UC in rats than live cells. Controversial results were yielded in some studies on the effects of Lactobacillus on ulcerative colitis (UC). In this work, we evaluated the effect of live or heat-killed Lactobacillus plantarum Zhang-LL cells and cell supernatants on dextran sulfate sodium (DSS)-induced UC in rats. The tested subjects were gavaged to rats for 7 days, and then 5% was used DSS repeatedly to induce chronic UC. The results of a 42-day experiment, indicated consistently and significantly that Both living and heat-killed cells of L. plantarum Zhang-LL could down-regulate content of pro-inflammatory cytokines (TNF-α, INF-γ) in serum, reduce intestinal permeability by increasing the expression of tight junction proteins zo-1, claudin-1 and occludin in colon tissue, and maintain intestinal microbiota stability by increasing intestinal microbiota diversity to alleviate the symptoms of chronic UC in rats with 100% survival rate. Of concern is, the heat-killed cells of L. plantarum Zhang-LL were more effective against DSS-induced chronic UC in rats.
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