Abstract
Diet influences health in multiple ways. One important effect of diet is on the gut microbiota. The effects of diet are often related to an individual's specific microbiota composition. The close links between health, diet, and gut microbiota are illustrated in a new mouse model of sepsis where the combination of a high-fat/low-fiber Western diet, antibiotics, and surgery promotes the development of lethal sepsis. Diet can also influence infection via the gut microbiota beyond sepsis. Future studies with this model may inform the use of microbiota analysis and personalized diets to protect surgery patients from infection and sepsis.
Highlights
The effects of dietary changes vary by individual and, in many cases, associate with specific gut microbiota members or compositions
In another study, feeding laboratory mice a diet low in microbiota-accessible carbohydrates (MACs) over multiple generations caused the apparent extinction of some members of the gut microbiota [5]
A new article by Hyoju et al highlights the interplay between diet, gut microbiota, and health with a mouse model of lethal sepsis that requires a Western diet, antibiotic treatment, and surgery [6]
Summary
The effects of dietary changes vary by individual and, in many cases, associate with specific gut microbiota members or compositions. A new article by Hyoju et al highlights the interplay between diet, gut microbiota, and health with a mouse model of lethal sepsis that requires a Western (high-fat/lowfiber) diet, antibiotic treatment, and surgery [6]. In the mouse model developed by Hyoju et al, 3 components are required for the development of lethal sepsis: Western diet, antibiotic treatment, and surgery (30% hepatectomy).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
