Abstract
The potentiometric response characteristics of lithium ion-selective membrane electrodes employing three different THF-type 16-crown-4 derivatives as ionophores were investigated. Of the THF- based crown compounds tested, a cis-type isomer of the derivative with only methyl groups (H/CH3) at four bridged positions (cis-THF-I) was found to exhibit the best selectivity for Li+ over other cations. The composition of the cis-THF-I-based PVC-matrix membrane was optimized and its performance was compared with those based on lithium ionophores reported previously. The new cis-THF-I-based membrane exhibits remarkably enhanced selectivities for lithium over other cations: logKpotLi,Na = –2.8, logKpotLi,K = –4.6, logKpotLi,NH4 = –5.4, logKpotLi,Ca = –5.7 and logKpotLi,Mg = –5.4. Furthermore, it was found that serum components do not interfere significantly with the lithium measurements when the cis-THF-I-based electrode is used. The response of the electrode was found to be linear in the clinical range of interest.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
