Lithium diisopropylamide ( LDA )

Abstract

This article has no abstract. Keywords: directed aldol condensation; alkylation of dialkylacetic acids; monoalkylation of alkylacetic acids; monoalkylation of toluic acids; synthesis of aldehydes and nitroparaffins; directed aldol condensation; α-hydroxymethylation of γ- and δ-lactones; lithium enolates of unsymmetrical ketones; α-methyl-γ-butyrolactone; monoalkylation of α,β-unsaturated ketones; synthesis of ketones; C-alkylation of cyclic α-diketones; β-hydroxy acids; α-alkylhydracrylic acids and α-alkylacrylic acids; hydrazobenzenes; allylic alcohols; stereoselective synthesis of trisubstituted olefins; α-alkylation of methyl hydracrylate; metalation of N,N-dialkyltoluamides; alkylation of lactones; lithiation of carboxylic acid esters; dibromomethyllithium; synthesis of 4-alkylcyclohexenones; spiroannelated cyclohexenones; β,γ-unsaturated ketones; β-hydroxy thiol esters; isomerization of cis-cyclooctene oxide; cyclization of a δ-chloro ester to a cyclobutane derivative; α-lithio selenoxides and selenides; examples; mixed malonates; regiospecific aldol condensations; metalation of 3-picoline; primary and secondary lithium derivatives of nitrosamines; examples; allyl selenide anions; examples; pyrroles; tetrahydropyridazines; 2,5-dialkylpyrrolidines; α-methylenelactones; alkylation of thioesters; α-hydroxycarboxamides; α,β-unsaturated ketones; shapiro-heath olefin synthesis; trianions of 2,4,6-triketones; conversion of endo-peroxides into furanes; preparation in hexane; lithium enolates of methyl ω-bromoalkyl ketones; indole synthesis; metalation of phenyl vinyl selenide (1); α-lithiation of phenoxyacetic acid; stereoselective aldol condensation; cyclopropanes from α,β-unsaturated carbonyl compounds; stobbe condensation; bis(trimethylsiloxy)cyclohexadienes; cyclization of 1,5-diketones; 1-alkyl-3-oxocyclohexenes; ketene thioacetals; alkoxy enediolates; epoxide isomerization; reduction of ketones; stereoselective aldol condensation; α-sulfenylation of dialkyl sulfoxides; allenes; aromatic rings by base-induced cyclizations; α-lithio selenides and selenoxides; reaction with phenyl vinyl selenide; deprotonation of β-lactones; α-alkylation of β-hydroxy carboxylic esters; α,β-enones; acylation of alkenes; 1-alkynes from methyl ketones; stork–danheiser alkylation; reaction with a hindered epoxide; claisen rearrangement of allyl α-hydroxy acetates; α-hydroxy-γ,δ-unsaturated acids; deconjugation of α,β-unsaturated esters; alkylation of cyclopropanecarboxylic acid esters; diastereoselective alkylation of tartaric acid; α-dialkylamino ketones; rearrangement of α-phenylselenenyl ketones; rearrangement of 2,4-alkadienoic esters; α-hydroxy-β-keto esters; succinic acids; γ-alkylation of α,β-enones; 2-; α-alkylation of α-halo ketones; 9-phenanthrols via directed lithiation; dianions of aldols; C-alkylation of polypeptides; ester enolates; directed lithiation; cyclopropanation; assorted anions; eliminations; directed lithiations; alkylations; aldol reactions; deprotonation; alkylations; double bond migration; demesylation; elimination; condensations; cyclization; cannizzaro and haller-bauer reactions; deprotonation; arylnaphthols; deacylation; tandem reactions