Liquid Chromatography Single Quadrupole Mass Spectrometry (LC/SQ MS) Analysis Reveals Presence of Novel Antineoplastic Metabolites in Ethanolic Extracts of Fruits and Leaves of Annona muricata

Yahaya Gavamukulya,Esther N Maina,Gabriel Magoma,Fred Wamunyokoli,Hany A El Shemy,Amos Meroka,Edwin S Madivoli

doi:10.5530/pj.2019.11.104

Yahaya Gavamukulya, Esther N Maina + Show 5 more

Open Access

https://doi.org/10.5530/pj.2019.11.104

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Journal: Pharmacognosy Journal	Publication Date: Jul 15, 2019
Citations: 3	License type: cc-by

Abstract

Pan African University, Busitema University, Uganda Natural Chemotherapeutics Research Institute, Uganda Directorate of Water Resources Management

Highlights

There is a global increase in the use of medicinal plants for health reasons
The current study suggests that ethanolic extracts of fruits and leaves of Annona muricata contain compounds which are potent antioxidant, antineoplastic and therapeutic agents for various conditions and paves the way for the development of several treatment regimens from these plant parts
The current study shows that Annona muricata contains various compounds which have been reported to have bioactivities against different conditions

Summary

Introduction

There is a global increase in the use of medicinal plants for health reasons. In developing countries, herbal drugs and traditional remedies are relatively more popular, because of cultural acceptability and belief that being natural, they are safe and nontoxic. There are some new approaches to drug discovery, such as combinatorial chemistry and computer based molecular modeling design, none of them can replace the importance of natural products in drug discovery and development.[1,2,3] Annona muricata L. is a species of the Annonaceae family that has been widely studied in the last decades due to its therapeutic potential. Objective: The aim of this study was to conduct LC MS analysis on the ethanolic extracts of fruits and leaves of Annona muricata for detection of novel metabolites. Results: The study revealed that the fruits extracts contain 1,3-Dimethylthiourea and (4-chlorophenyl)-[4-(3-chlorophenyl)-2-[(Z)-3-(dimethylamino) prop-1-enyl]quinolin-6-yl]-(3-methylimidazol-4-yl)methanol, which are reported antioxidant and antineoplastic agents. Conclusion: The current study suggests that ethanolic extracts of fruits and leaves of Annona muricata contain compounds which are potent antioxidant, antineoplastic and therapeutic agents for various conditions and paves the way for the development of several treatment regimens from these plant parts.

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