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Abstract
BackgroundLymphedema is a progressive, noncurable condition consisting of increases in subcutaneous fat and interstitial fluid in the limbs and fibrosis during later stages. The disease most commonly affects the limbs following injury to or removal of the lymph nodes. The aim of this study was to investigate the therapeutic outcomes of liposuction for cancer-related lower extremity lymphedema.MethodsSixty-two patients with cancer-related lymphedema in the unilateral lower extremity were recruited for this study, and all patients underwent liposuction. The volume of hemorrhage and lipids, the operation time, and the volume changes of the affected extremity were compared by applying the t tests, and the subjective feelings of patients were compared with the chi-square tests.ResultsThe total lipid volume was 2539 ± 1253.5 ml, and the hemorrhage volume was 828 ± 311.8 ml. For the comparison of objective indices, (1) the percent volume differences (PVDs) before surgery, intraoperatively, and at the 3-month follow-up were 5.5 ± 12.2 vs. 11.6 ± 18.4 vs. 43.2 ± 23.7, P < 0.05, respectively; (2) greater lipid volumes and higher liposuction rates were observed for female patients, as was a smaller volume of hemorrhage; (3) greater hemorrhage volumes were observed in patients with a history of recurrent erysipelas; and (4) greater lipid volumes and liposuction rates (LRs) and smaller hemorrhage volumes were observed for stage II than for stage III patients.ConclusionsLiposuction is an effective therapy for cancer-related lower extremity lymphedema. Sex, stage, and recurrent erysipelas history influence the course and effect of liposuction.
Highlights
Pelvic tumor surgery is traditionally characterized by several major complications, including secondary lower extremity lymphedema [1]
Cancer-related lower extremity lymphedema is associated with treatment modalities such as cancer surgery and radiation therapy, which can injure or remove the lymph nodes [2, 3]
Brorson reported that liposuction combined with postoperative controlled compression therapy (CCT) is effective for the treatment of limb lymphedema [9]
Summary
Pelvic tumor surgery is traditionally characterized by several major complications, including secondary lower extremity lymphedema [1]. Cancer-related lower extremity lymphedema is associated with treatment modalities such as cancer surgery and radiation therapy, which can injure or remove the lymph nodes [2, 3]. Xin et al World Journal of Surgical Oncology (2022) 20:6 therapeutic effect of liposuction for lymphedema is still controversial. Brorson reported that liposuction combined with postoperative controlled compression therapy (CCT) is effective for the treatment of limb lymphedema [9]. Other researchers have found that liposuction can significantly reduce lymphedema limb volume, but excess extracellular fluid persists [13]. The aim of this study was to investigate the therapeutic outcomes of liposuction for cancer-related lower extremity lymphedema
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