Abstract
Groups of rabbits were immunized with β-lipoproteins isolated from serum of normal and cholesterol-fed chickens. Precipitin titers in excess of 5000: 1 were developed against antigen protein from cholesterol-fed birds. Plasma lipid levels increased in immunized animals and increase paralleled development of precipitin titers. Rabbit serum was analyzed by chromatography on DEAE cellulose ion exchange resin. Cholesterol in normal serum was found almost exclusively in proteins having the electrophoretic characteristics of α-globulins. Following immunization, significant quantities of cholesterol were found in γ-globulins in rabbits on both normal and on cholesterol-supplemented diets. Immunized and control animals were fed a diet supplemented with 2% cholesterol for 12 weeks. Development of atherosclerosis in thoracic aorta was not significantly different in normal and immunized rabbits. Lipid levels in serum and tissues also were not significantly reduced by the prior immunization procedure. When immunization was carried out subsequent to cholesterol feeding, intensity of atherosclerosic plaques did not decrease in 6 weeks following transfer to normal diet whereas serum lipids returned to normal at same rate in control and immunized animals during this period.
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