Abstract
Lipopolysaccharide assembly in the bacterial outer membrane revealed by X-ray crystallography.
Highlights
Lipopolysaccharide (LPS), termed endotoxin, is a main component of the external leaflet of the outer membrane (OM) in Gram-negative bacteria
As LPS is essential to most Gramnegative bacteria, intervening in LPS biogenesis offers great opportunities for developing novel antibiotics against pathogens
For a long time, it is unclear how LPS is transported across the periplasm and assembled in the external leaflet of the OM in Gram-negative bacteria
Summary
Lipopolysaccharide (LPS), termed endotoxin, is a main component of the external leaflet of the outer membrane (OM) in Gram-negative bacteria. As LPS is essential to most Gramnegative bacteria, intervening in LPS biogenesis offers great opportunities for developing novel antibiotics against pathogens.
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