Abstract
Gram‐negative bacteria can survive in harsh environments in part because of the presence of the outer membrane (OM), which comprises lipopolysaccharides (LPS) and phospholipids (PLs) in the outer and inner leaflets, respectively. This asymmetric distribution of lipids renders the OM a very effective permeability barrier against toxic compounds, including bile salts and hydrophobic antibiotics. To build a stable OM with the requisite lipid asymmetry, the transport and assembly of LPS, PLs and OM proteins into the OM must be coordinated. While assembly pathways for LPS and OM proteins have been well‐characterized, the processes by which PLs are transported to and from the OM, and their coordination with these other systems, are much less understood. In this talk, I will describe our work in understanding and characterizing PL transport systems in Escherichia coli, and discuss how these systems function in maintaining lipid homeostasis in the OM.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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