Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health.

Irma Magaly Rivas Serna,Jose R Medina-Inojosa,Michal Sitina,Gorazd B Stokin,Manlio Vinciguerra,Juan P Gonzalez-Rivas,Francisco Lopez-Jimenez

doi:10.3390/metabo11110747

Abstract

Ideal cardiovascular health (CVH) is defined for the presence of ideal behavioral and health metrics known to prevent cardiovascular disease (CVD). The association of circulatory phospho- and sphingo-lipids to primary reduction in cardiovascular risk is unclear. Our aim was to determine the association of CVH metrics with the circulating lipid profile of a population-based cohort. Serum sphingolipid and phospholipid species were extracted from 461 patients of the randomly selected prospective Kardiovize study based on Brno, Czech Republic. Lipids species were measured by a hyphenated mass spectrometry technique, and were associated with poor CVH scores, as defined by the American Heart Association. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE) species were significantly lower in ideal and intermediate scores of health dietary metric, blood pressure, total cholesterol and blood fasting glucose compared to poor scores. Current smokers presented higher levels of PC, PE and LPE individual species compared to non-smokers. Ceramide (Cer) d18:1/14:0 was altered in poor blood pressure, total cholesterol and fasting blood glucose metrics. Poor cardiovascular health metric is associated with a specific phospho- and sphingolipid pattern. Circulatory lipid profiling is a potential biomarker to refine cardiovascular health status in primary prevention strategies.

Highlights

In 2010, the AHA suggested an ideal cardiovascular health (CVH) score to improve the cardiovascular health of the American population by
The healthy dietary metric is composed of intermediate scores (96.7%) and poor scored (3.3%)
The cardiovascular health parameters from an ideal to a poor score were associated with different concentrationshealth of circulatory sphingolipids phospholipids

Summary

Introduction

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cardiovascular diseases (CVD) represent the most common cause of mortality and morbidity among adults with roughly 30% of deaths worldwide [1]. The most important behavioral risk factors of CVD are unhealthy diet, physical inactivity, and tobacco use. The effects of these behavioral risk factors may cause hypertension, dysglycemia, dyslipidemia and overweight/obesity. In 2010, the AHA suggested an ideal cardiovascular health (CVH) score to improve the cardiovascular health of the American population by

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