Abstract

Cellular uptake of two series of lipidic amino acid and peptides 1a–1c, benzoquinolizine 2a and conjugates 2b–2d was studied. The lipidic amino acid methyl ester 1a and benzoquinolizine monomer conjugate 2b were taken up by erythrocytes, E. coli and hepatocytes more readily and to a greater extent than the fully protected dipeptide 1b, tripeptide 1c and conjugates 2c and 2d. It is believed that the dimer 1b, trimer 1c and the conjugates 2c and 2d, due to their increased lipophilic structures are retained in the plasma membrane. Metabolism of the conjugate 2b in red blood cells was slow; after 30 min incubation no significant metabolites were detected.

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