Lipid-soluble cigarette smoke particles induced vascular endothelin type B receptor regulation through AMPK-SIRT1 and ERK1/2 signal pathways.

Abstract

Background and Aims: Smoking is a well-known risk factor that increases cardiovascular diseases (CVDs). Endothelin type B (ETB) receptors were involved in the pathogenesis of CVDs. However, Sirtuin 1(Sirt1) has potential protect roles for CVDs. However, the molecular mechanisms by which smoking leads to vasospasm and cardiovascular disease are not fully understood. This study was designed to examine whether DMSO-extracted cigarette smoke particles (DSP) could induce up-regulation of vascular endothelin type B (ETB) receptors, and whether ETB receptor is up-regulated through AMPK-Sirt1 and ERK1/2 Signal Pathways.