Abstract
Background: It has been reported that ischemia-reperfusion is associated with augmentation of oxidative stress and its specific and sensitive markers. Oxidative stress may cause atrial fibrillation (AF) which is a common consequence after cardiac surgery. Dietary supplementation with antioxidants might lower the incidence of AF following coronary artery bypass graft (CABG) surgery. Materials and Methods: Fifty patients with coronary heart disease (CHD) referred to Namazi and Faghihi Hospitals in Shiraz, undergone elective CABG, were enrolled in this study. For evaluation of oxidative stress, whole blood was taken before and 24 hours after surgery and malondialdehyde (MDA) as an oxidative marker and glutathione (GSH) as an antioxidant marker were measured. Results: Results showed a significant difference between the mean concentration of GSH before and after CABG surgery (P <0.05); however, the difference in plasma MDA levels before and after CABG was insignificant. Conclusion: CABG surgery results in oxidative stress and reduces GSH 24h after surgery and administration of antioxidants may attenuate post-operative oxidative stress. [GMJ.2015;4(2):78-82]
Highlights
Oxidative stress has a critical role in pathophysiology of atherosclerosis and acute thrombotic events including dyslipidemia leading to oxidation of low density lipoprotein (LDL), atheroma formation, plaque rupture and recurrent thrombosis
The results showed a significant difference between mean concentration of GSH before (1192.32 μm/l) and af
coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) and cardiac arrest induce an inflammatory response and reperfusion of this ischemic organ is the only way to limit ischemic damage but on the other hand, it leads to the generation of oxidative stress, which can cause post-ischemic tissue injury [13]
Summary
Oxidative stress has a critical role in pathophysiology of atherosclerosis and acute thrombotic events including dyslipidemia leading to oxidation of low density lipoprotein (LDL), atheroma formation, plaque rupture and recurrent thrombosis. The tissue releases reactive oxygen species (ROS) which are specific and sensitive markers for inflammation and oxidative stress. We aimed to compare lipid peroxidation product malondialdehyde (MDA) levels and glutathione (GSH) levels in patients with coronary heart disease before and 24h after CABG surgery. It has been reported that ischemia-reperfusion is associated with augmentation of oxidative stress and its specific and sensitive markers. Oxidative stress may cause atrial fibrillation (AF) which is a common consequence after cardiac surgery. Dietary supplementation with antioxidants might lower the incidence of AF following coronary artery bypass graft (CABG) surgery.Materials and Methods: Fifty patients with coronary heart disease (CHD) referred to Namazi and Faghihi Hospitals in Shiraz, undergone elective CABG, were enrolled in this study. For evaluation of oxidative stress, whole blood was taken before and 24 hours after surgery and malondialdehyde (MDA) as an oxidative marker and glutathione (GSH) as an antioxidant marker were measured.Results: Results showed a significant difference between the mean concentration of GSH before and after CABG surgery (P
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