Lipid peroxidation in female dogs bearing mammary gland carcinomas

I.B Souza,C.V Cardoso,S.C Poppe,E.F Bondan

doi:10.1590/1678-4162-9751

Abstract

Lipid peroxidation in female dogs bearing mammary gland carcinomas

Highlights

Oxidative damage to cellular macromolecules, such as lipids, proteins and nucleic acids, by increased production of reactive oxygen species (ROS) is suggested to be involved in the pathogenesis of malignant tumors
Eighteen of them were grouped in group I after receiving histopathologic diagnosis of simple tubular mammary carcinoma staged as Stage 4 [T - any tumor size; N1; M0] according to the T, N and M system (Sorenmo et al, 2013), and 18 healthy female dogs were included in group II
One milliliter was treated with the anticoagulant EDTA and used for complete blood cell count and determination of hemoparasites; the remainder was used to determine thiobarbituric acid reactive substances (TBARS) concentrations according to Fraga et al (1988), with the results expressed in micromoles of TBARS per milliliter of plasma

Summary

Introduction

Oxidative damage to cellular macromolecules, such as lipids, proteins and nucleic acids, by increased production of reactive oxygen species (ROS) is suggested to be involved in the pathogenesis of malignant tumors. While Kumaraguruparan et al (2005) observed higher TBARS levels in bitches bearing mammary adenocarcinomas relative to healthy females, other studies involving dogs with lymphomas (Winter et al, 2009) and mammary neoplasms (Szczubial et al, 2004) did not show significant differences compared to control animals.

Results

Conclusion