Lipid peroxidation and inguinal hernia repair. Tension-free vs. Andrews technique

Abstract

Aim of the study: To evaluate the early effect of inguinal hernia repair by the tension-free method compared to the conventional Andrew's technique on lipid peroxidation. Patients-methods: Thirty-four patients subjected to elective hernia repair were enrolled in the study divided in two groups. Group A (n=18) underwent hernia repair by the tension-free method using a polypropylene mesh. Group B (n=16) underwent hernia repair by the Andrew's technique (i.e. a modification of the Bassini's technique). Venous blood samples were drawn preoperatively and at 12, 24 and 48h postoperatively. Malondialdehyde (MDA) was estimated by the thiobarbiturate assay. Results: Neutrophil counts were significantly higher in patients of group B compared to group A at 12 and 48h postoperatively. Concentrations of fibrinogen were similar between the two groups. MDA was significantly higher in patients of group B hours compared to group A at 12, 24 and 48h postoperatively. Positive correlation was found between neutrophil counts and MDA at 12h (r: +0.43, P: 0.015) and 48h (r: +0.496, P: 0.005) but not at 24h. No correlation was found between serum fibrinogen and MDA. Conclusion: Hernia repair by the Andrews's technique elicits a sustained triggering of lipid peroxidation, compared to the tension-free method.