Abstract
Postprandial lipemia influences the development of atherosclerosis. Age has been defined as a regulating factor of the extent of postprandial lipemia, but its independence of other age-associated phenotypic features, such as metabolic syndrome, has not been fully elucidated. To investigate if age is an independent factor influencing postprandial lipemia, we compared the lipemic response to a rich fatty meal (60% fat) of 88 healthy young men (<30 years old) and 97 older participants (77 metabolic syndrome patients aged>40; and 20 healthy people>65) (all ApoE3/E3), at fasting state and at 2nd and 4th postprandial hours. We didn't find differences between the healthy young men and the healthy elderly. The metabolic syndrome patients displayed a higher postprandial TG area below the curve than the other two cohorts p<0.001. ANOVA for repeated measurements confirmed that these differences were significant at every time-point (fasting, 2h and 4h). Concomitant higher responses for Large and Small TRL-carried TG and Chol were found in these metabolic syndrome patients. Interestingly, the most significant differences were found for Small-TRL-carried particles, which suggest that this fact may be mainly due to impaired lipid clearance. Metabolic syndrome may account for the differences in postprandial lipemia that have been attributed to age. In our study, there were no significant differences in postprandial lipemia between a young population (mean age 22.6 years) and a healthy people >65 years one (67.2 years) without metabolic syndrome.
Published Version
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