Lipid lowering potential and potentiation effect of curcumin and atorvastatin in-patient with hyperlipidemia

Abstract

Hyperlipidemiais a term that refers to any of several acquired or genetic disorders that result in a high level of circulating lipids (fats, cholesterol and triglycerides). The condition can affect one fat protein or several. Most people will have no symptoms, with increasing the risk of developing heart problem. It has been found that oxidation processes play important role in developing lipids disorders. Curcumin is a phytochemical antioxidant substance may play a role in lowering lipids levels in the blood.This study was conducted to evaluate the lipid lowering effect of curcumin in Iraqi patients with hyperlipidemia and to study the potentiation effect on atorvastatin.From thosepatients who attendedMedical Clinic in Al-Diwanyiah Teaching Hospital,48 patients of 45-65 years old with diagnosed hyperlipidemia were enrolled in this study,they were divided randomlyinto four groups,12 patients in each. Base line assessment was done in form oflipid profile. 1stgroup was considered as placebo,2ndgroups received atorvastatin,3rd group received curcumin and 4th group received atorvastatin + curcumin. Reassessment was done after 2 months.Curcumin group shows significant reduction in TG (P ≤ o.o5), significant reduction of LDL in atorvastatin group (P≤ 0.05) and highly significant reduction in LDL,TG,and significant reduction in TC in patients received both atorvastatin + curcumin,with no significanteffects on HDL in all treated groups,compared to placebo.curcumin express lipid lowering activity and potentiate atorvastatin action in patient with hyperlipidemia.