Lipid lowering influence of ethyl p-chlorophenoxyisobutyrate in liver of rats fed high fat diets

Abstract

The effect of CPIB on total lipid, total cholesterol, and triglyceride concentration in liver was studied in rats maintained on diets with three different fats at the level of 20 per cent. Half of the diets were supplemented with exogenous cholesterol. Rats given food without CPIB served as control animals to the other half which received dietary CPIB treatment. The type of fat showed a marked effect on total lipid, total cholesterol, and triglyceride level in the liver of rats. Contrary to our findings in serum,5 CPIB showed a definite and remarkable lowering effect on total cholesterol and triglyceride levels in the liver of the rats not supplemented with dietary cholesterol. With exogenous cholesterol in the diet total liver cholesterol level failed to show any lowering effect of CPIB. However, consistent and notable lowering in liver triglyceride was observed in rats administered CPIB despite exogenous dietary cholesterol. The present findings indicate that type of fat and presence of dietary cholesterol are important factors in the degree of lipid lowering that can be brought about by CPIB administration. The serum lipid elevations and definite lowering noted in the liver in response to these diets may be suggestive that the influence of CPIB on the equilibrium between liver and plasma depends upon the level and type of dietary fat. The effect of CPIB on total lipid, total cholesterol, and triglyceride concentration in liver was studied in rats maintained on diets with three different fats at the level of 20 per cent. Half of the diets were supplemented with exogenous cholesterol. Rats given food without CPIB served as control animals to the other half which received dietary CPIB treatment. The type of fat showed a marked effect on total lipid, total cholesterol, and triglyceride level in the liver of rats. Contrary to our findings in serum,5 CPIB showed a definite and remarkable lowering effect on total cholesterol and triglyceride levels in the liver of the rats not supplemented with dietary cholesterol. With exogenous cholesterol in the diet total liver cholesterol level failed to show any lowering effect of CPIB. However, consistent and notable lowering in liver triglyceride was observed in rats administered CPIB despite exogenous dietary cholesterol. The present findings indicate that type of fat and presence of dietary cholesterol are important factors in the degree of lipid lowering that can be brought about by CPIB administration. The serum lipid elevations and definite lowering noted in the liver in response to these diets may be suggestive that the influence of CPIB on the equilibrium between liver and plasma depends upon the level and type of dietary fat.