Abstract
Lipid composition of sarcolemma, mitochondria, and fragmented sarcoplasmic reticulum (FSR) from newborn and adult cardiac muscles was examined. Experiments were performed on newborn (0–3 days old) and adult white rabbits. In the newborn cardiac muscles, total lipid, phospholipid, and cholesterol contents in sarcolemma, mitochondria, and FSR were significantly higher than those of adult cardiac muscles. From 75 to 80% of total phospholipids in each subcellular fraction was attributed to the major phospholipid components, phosphatidylcholine and phosphatidylethanolamine. The phospholipid composition, however, was not statistically different in newborn and adult cardiac muscles except for the phosphatidylserine in the sarcolemmal fraction. The proportion of fatty acid in neutral lipid was high in palmitic acid and low in arachidonic acid in contrast to the proportion of phospholipid. The proportions of saturated fatty acids of phospholipids in each fraction of newborn cardiac muscle were higher than those of adult cardiac muscle. Each of the cell fractions from newborn and adult cardiac muscles showed a distinct fatty acid pattern in the phospholipid and neutral lipid fractions.
Published Version
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