Abstract
Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization. Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macro- and micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs. Particulate type carrier also known as colloidal carrier system, includes lipid particles, micro- and nanoparticles, micro- and nanospheres, polymeric micelles and vesicular systems like liposomes, sphingosomes, niosomes, transfersomes, aquasomes, ufasomes, and so forth.
Highlights
In the past few decades, considerable attention has been paid to the development of novel drug delivery system
The novel drug delivery systems aim to fulfill two prerequisites; that is, it delivers the drug at a rate directed by the needs of the body, over the period of treatment, and it carries the drug directly to the inflamed tissues and/or organ
Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macroand micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs
Summary
In the past few decades, considerable attention has been paid to the development of novel drug delivery system. Novel drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization. Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macroand micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs. Vesicular drug delivery systems are important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. (ii) Poor encapsulation efficiency for hydrophilic drug. (iii) Liposomes are expensive. (iv) Liposomes possess short half-life
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