Abstract
Flat palpebrai xanthelasmas are described by Hogan and Zimmerman as xanthomatosis without hypercholesterolemia, in which a qualitative rather than quantitative defect of lipid metabolism or transport is at fault. Others · have implicated factors at the cel lular level, which cause the deposition of cholesterol in histiocytes. In xanthelasmas, this tissue-factor was believed restricted to the palpebrai foam-cell nests, in contrast to the systemic forms of xanthomatosis with out hypercholesterolemia (Hand-SchullerChristian disease, Letterer-Siwe disease, and even eosinophil granuloma or nevoxanthoendothelioma). The frequency of coro nary artery disease in females afflicted with plain xanthelasmassuggests a general rather than local deposition of cholesterol. Xanthelasma is the most common type of xanthomas and is readily available for chemical analysis. It seemed promising to study the lipids of the xanthelasma itself, to learn which are its main lipid fractions. Comparative studies were then made of the patients' blood. Erythrocyte lipids are in dy namic equilibrium with serum lipids,· therefore the erythrocyte lipid surface which is easily accessible for study was in vestigated as one of the sites of a lipid-binding tissue factor.
Published Version
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