Abstract
AbstractThe medical devices when they implanted or inserted into human body become the sites of competition between host cell integration and microbial adhesion while exerting the intended purpose like salvage of normal functions of vital organs. Different approaches either to enhance the efficiency of certain antimicrobial agents or to disrupt the basic physiology of the pathogenic microorganisms, including novel small molecules and antipathogenic drugs are already being employed to control microbial colonization and subsequent biofilm formation onto the medical devices. Recently, various lipid-and polymer-based drug delivery carriers are also investigated for applying antibiofilm coating onto the medical devices especially over catheters. To ensure systematic release of antimicrobial agents into the surrounding vicinity of an implanted medical device and, furthermore, provide sufficient initial and subsequent antimicrobial substance release, the antimicrobial substance are being incorporated into a controlled releasing polymer system, and then used to coat over medical devices. This book chapter summarizes the major and/breakthrough inventions disclosed in patent literature as well as in research papers showing the potential of lipid-and polymer-based drug delivery carriers to eradicate microbial biofilm causing medical device-related infections. With this coverage, this book chapter therefore provides a range of lipid and polymer-based drug delivery carrier is available for the medical scientist to develop a medical device with antibiofilm property.KeywordsMedical DeviceChronic Granulomatous DiseaseCationic LiposomeUsnic AcidMicrobial AdhesionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Published Version
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