Abstract
Many of the changes that occur in the rat cardiac muscle with advancing age are related to modifications in membrane fatty acid composition, polyunsaturated fatty acids decreasing and saturated increasing as the animal develops. In the present study, using cultured adult cardiomyocytes isolated from the hearts of rats of a broad (1-24 months) age range, we demonstrated that the modifications in the fatty acid pattern of cardiomyocytes have to be related to alterations in the mechanism of desaturation/elongation of essential fatty acids. In fact, independent of the age of the animal, heart cells in culture were capable of rapidly metabolizing radiolabeled linoleic acid taken up from the surrounding medium, but to a different extent. The ability of heart cells to metabolize linoleic acid to higher and more unsaturated metabolites decreased with the animal's age. As the age of the animal increased, the pattern of fatty acids of the cultured cardiomyocytes showed a gradual but significant shift, similar to those reported in the whole heart. Data here reported confirm that the basic aging-related process in the cellular model system may also be relevant to aging in the whole animal.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
