Abstract
Translation initiation is a tightly regulated step in eukaryotic translation that involves a large set of initiation factors (eIFs). Deregulation leads to altered gene expression, tumor formation and cancer. Translation initiation requires unwinding of secondary structures in the 5’-UTR of mRNAs by the DEAD-box helicase eIF4A, an RNA-dependent ATPase and ATP-dependent helicase. Together with the cap-binding protein eIF4E and the scaffold protein eIF4G, eIF4A forms the eIF4F complex that recognizes the 5’-cap and, assisted by eIF4B, recruits the 40S ribosomal subunit.
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