Abstract
The Fcγ receptor cluster on chromosome 1q23 contains a number of genes that may affect susceptibility to celiac disease, but previous studies have yielded contradictory results. We studied the FcγRIIa*A519G (rs1801274) and FcγRIIIa*A559C (rs396991) single nucleotide polymorphisms in celiac disease families from Hungary and Finland and in celiac disease case–control materials from Hungary and Italy. Neither the Hungarian nor the Italian case–control material or a meta-analysis of the combined case–control material showed significant single-marker or haplotype association. In addition, neither linkage nor family-based association tests showed evidence for association in the Finnish or Hungarian family material. This study thus does not support a previous publication showing FcγR association with celiac disease.
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