Abstract
Folding of nascent chains resembles the decoding of spoken language in that information is emitted as a unidirectional, one-dimensional string of elements, with higher structures and long-distance interactions emerging with time. Applying a ‘pseudolinguistic’ analysis of structure to a set of all 36 possible six-stranded antiparallel β-sandwich topologies reveals new order principles and reduces the complexity of this family significantly. The simple connectivity diagrams (‘linguistic trees’) proposed here allow predictions of the speed and cooperativity of β-sheet folding and help understanding the cotranslational folding from the N-terminus.
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