Abstract
This report demonstrates the protective action of Teflon linings on the sorption and leaching characteristics of polyurethan and natural rubber stoppers. This lining was effective in essentially eliminating extractives from appearing in water, 50 per cent polyethylene glycol 300, 50 per cent <i>N</i>, <i>N</i>-dimethylacetamide, 10 per cent ethanol, and 2 per cent benzyl alcohol when these solvents were in contact with the closures for 6hr. at 115°. Sorption of the preservative, <i>p</i>-chloro-<i>β</i>-phenylethyl alcohol, from aqueous solution was effectively retarded by the Teflon lining on the stoppers. Reduced protection against sorption and leaching was found when Teflon lined closures, which previously underwent multiple puncture with a 20-gauge hypodermic needle, were used.
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