Abstract
Studies of the separation of benzyl, phenylethyl and phenylpropyl alcohols by flash chromatography (FC) on 1.0 × 30 or 1.9 × 15 cm silica gel columns are compared with separation by countercurrent chromatography (CCC) on a 1.68 mm × 24 m, 56 mL, PTFE multilayer coil. Neither adjacent pair of alcohols could be separated by FC and separation of benzyl from phenylpropyl alcohol was poor. The small coil separation by CCC provided a resolution of 0.91 to 1.01 for benzyl and phenylethyl alcohols and better than baseline resolution of phenylpropyl alcohol from either benzyl or phenylethyl alcohol. Speed, sample capacity and selectivity of the two separation techniques are similar but resolution by CCC is enhanced by the characteristic symmetry of CCC peaks compared with the severe tailing observed in FC. †Present address: Pfizer Inc., Central Research Division, Eastern Point Road, Groton, CT 06340.
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