Abstract
BackgroundThe data with regards to the regional variants of distinct HPV types is of great value. Accordance with this, this study aimed to investigate the sequence variations of E6 gene and long control region of HPV 39 among normal, premalignant and malignant cervical samples in order to characterize the frequent HPV 39 variants circulating in Tehran, Iran.MethodsIn total, 70 cervical samples (45 normal, 16 premalignant, and 9 malignant samples) infected with HPV 39 were analyzed by nested-PCR and sequencing.ResultsOur results revealed that all samples belonged to A lineage. Almost all sequences (98.6%) were classified in A1 sublineage and only one sample (1.4%) was A2 sub lineage.ConclusionsOur findings showed that lineages A, sublineage A1, is dominant in Tehran, Iran. However, the small sample size was the most important limitations of this study. Further studies with larger sample size from different geographical regions of Iran are necessary to estimate the pathogenicity risk of HPV 39 variants in this population.
Highlights
Cervical cancer is reported as the fourth most frequent cancer among women worldwide [1]
Most studies on the prevalence of Human papillomavirus (HPV) types has indicated that HPV 16 and 18 are the most prevalent types in women with normal cervical cytology and invasive cervical cancer in Iran [8,9,10,11,12,13]
Regard to above-mentioned data that HPV 39 is one of the five most common HPV types in Iranian women with cervical cancer [14], this study aimed to investigate the frequent HPV 39 variants circulating in Iran
Summary
Cervical cancer is reported as the fourth most frequent cancer among women worldwide [1]. Among high-risk HPV types, HPV 16 and 18 are leading cause and responsible for almost 72% of cervical cancer [7]. Most studies on the prevalence of HPV types has indicated that HPV 16 and 18 are the most prevalent types in women with normal cervical cytology and invasive cervical cancer in Iran [8,9,10,11,12,13]. The data with regards to the regional variants of distinct HPV types is of great value. Accordance with this, this study aimed to investigate the sequence variations of E6 gene and long control region of HPV 39 among normal, premalignant and malignant cervical samples in order to characterize the frequent HPV 39 variants circulating in Tehran, Iran
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