Abstract
Abstract The stereoselective reduction of alkynes to cis ‐alkenes by hydrogen in the presence of palladium that is tinctured onto calcium carbonate and then deactivated by lead acetate and quinoline is often known as the Lindlar reduction or Lindlar hydrogenation. The palladium on calcium carbonate poisoned with lead acetate and quinoline is referred to as the Lindlar catalyst. The study finds that the addition of quinoline lowers the reduction rate but efficiently enhances the selectivity by inhibiting alkene surface interaction. The addition of lead acetate has been suggested to block the most active catalyst sites and prevent overreduction of alkenes to alkanes. It has been reported that the cis / trans ratio has been enhanced by changing the solvent. The palladium on Al 2 O 3 is found to be superior to the Lindlar catalyst operating under same conditions. This reaction has broad application in natural product synthesis.
Published Version
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