Abstract

Acute gastric mucosal lesions refer to acute inflammation of the gastric mucosa [1,2], Symptoms including gastric mucosal congestion, edema, and erosion...

Highlights

  • Malignant peripheral nerve sheath tumor (MPNST) is a rare subtype of soft tissue sarcoma originating from the cells of peripheral nerve sheaths, and a relatively poor prognosis may be associated with MPNST due to the risk of recurrence and metastasis [1-6]

  • We evaluated the impact of multimodality imaging to improve radiation therapy (RT) target volume definition for MPNST

  • Results of our study revealed that ground truth target volume was identical with target volume determination with computed tomography (CT)-MR fusion based imaging

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Summary

Introduction

Malignant peripheral nerve sheath tumor (MPNST) is a rare subtype of soft tissue sarcoma originating from the cells of peripheral nerve sheaths, and a relatively poor prognosis may be associated with MPNST due to the risk of recurrence and metastasis [1-6]. Both children and adults may be affected with MPNST, and an association has been found between neuro fibromatozis type 1 and MPNST development. Radiation induced adverse effects constitute a formidable challenge in management of MPNST with RT. Within this context, extensive effort has been focused on improving the toxicity profile of radiation delivery. We evaluated the impact of multimodality imaging to improve RT target volume definition for MPNST

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