Abstract
Limb Ischemic Preconditioning or Dezocine Pre-Treatment will Reduce Acute Gastric Mucosal Injury in Rats
Highlights
Acute gastric mucosal lesions refer to acute inflammation of the gastric mucosa [1,2], Symptoms including gastric mucosal congestion, edema, and erosion [3,4,5]
We designed a comparison between Limb ischemic preconditioning (LIPc) and Dezocine Pre-treatment in rats to observe their protective effects on gastric mucosa under acute stress
Superoxide Dismutase (SOD) in Group T and Group D was significantly higher than that in Group C, (P
Summary
Forty-five Sprague Dawley (SD) male rats at 2-3 month were randomly divided into three groups: controlled group (Group C, n=15), Ischemic precondition group (Group T, n=15): rats in this group received 5 cycles of ischemic precondition of 5-5 min in their left legs; Dezocine pre-treatment group (Group D, n=15): Rats in this group received Dezocine subcutaneous injection at a dosage of 10μg/g. Rats were beheaded after 6h of cold water immerse, and stomach was taken out for Gastric injury index (GI), HE stains, and measurement of MDA, SOD, MPA
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