Abstract
Combination therapy based on precise phototherapies combined withimmunemodulation provides successful antitumor effects. In this study, a combination therapy is designed based on phototactic, photosynthetic, and phototherapeutic Chlamydomonas Reinhardtii (CHL)-glycol chitosan (GCS)-polypyrrole (PPy) nanoparticle (NP)-enhanced immunity combined with the tumor microenvironment turnover of cytotoxic Tcells and M1/M2 macrophages, which is based on photothermal GCS-PPy NPsdecorated onto the phototactic and photosyntheticCHL. Phototherapy based on CHL-GCS-PPy NPs alleviates hypoxia and modulates the tumor immunemicroenvironment, which induces tumor cell death. In particular, the precise antitumor immune response and potent immune memory induced by combining self-navigated phototherapies significantly alleviate the progression of bladder cancer in C57BL/6 mice and effectively inhibit bladder tumor growth. Furthermore, they also potentially prevent tumor recurrence, which provides a promising therapeutic strategy for clinical tumor therapy.
Published Version
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