Ligand-exchange chromatography of racemates : VI. Separation of optical isomers of amino acids on polystyrene resins containing l-proline or l-azetidine carboxylic acid

Abstract

Optical isomers of amino acids have been separated on the copper form of asymmetric resins containing residues f heterocyclic l- a-amino acids (proline and azetidine carboxylic acid) on a cross-linked polystyrene matrix. The enantioselectivity of the sorbents with respect to the optical isomers of many amino acids is high enough (200–800 cal/mole) to allow their quantitative separation. The separating capacity of the sorbent containing l-proline residues is generally higher than that of the sorbent based on l-azetidine carbocylic acid.