Abstract
Publisher Summary When rat pituitary glands are continuously exposed to luteinizing hormone-releasing hormone (LH–RH), a pattern of luteinizing hormone (LH) secretion is induced, which is essentially characterized by three phases: (1) a lag phase during which LH release is elevated to a relatively small extent, (2) a secondary phase during which LH secretion further increases, and (3) a phase of refractoriness during which LH secretion decreases again, in spite of the presence of LH–RH. This chapter discusses the effects of LH–RH on the pituitary gland of the rat. A high amount of protein factor in itself does not enhance LH secretion. LH–RH induces LH release by two mechanisms: one is the synthesis of protein factor, the amount of which determines how much LH can be released, and the second is a “direct” action, which can be envisaged to activate the release machinery by itself. The overall effects of oestradiol on LH secretion are mediated through changes of hypothalamic LH–RH release. Parts of the pattern of pituitary responsiveness to LH–RH, as induced by oestrogens, are the result of the hypothalamic effects.
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