Abstract
A decrease in pituitary LH with a concomitant increase in plasma LH was observed in adult intact female rats injected subcutaneously with 17β-estradiol (0.6 μg/kg) for 7 days. This observation indicates that estradiol is capable of stimulating LH release when administered in a relatively small dose. An estrogen antagonist (CN-55,945-27), which is mildly estrogenic, had no significant effect in preventing the decrease in pituitary LH caused by estradiol treatment. However, the compound (25 μg/kg, orally) did prevent the increase in plasma LH observed with estradiol. This effect was probably due to an additive action between estradiol and CN-55, 945-27 to produce the negative feedback effect of estrogen on LH secretion. Thus, relatively low doses of estrogen are capable of stimulating the release of LH, whereas higher doses inhibit LH secretion. (Endocrinology 79: 455, 1966)
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