Levels of serum platelet-derived growth factor-Ꞵ (PDGF-Ꞵ) and factors affecting mortality in patients with acute myocardial infarction

Abstract

Acute myocardial infarction (AMI) is the necrosis in the heart tissue resulting from obstruction of the coronary arteries. The main phenomenon in coronary artery disease and the formation of acute coronary syndromes is atherosclerosis which develops following the formation of coronary plaque. Platelet-derived growth factors (PDGF) that are produced by platelets, macrophages and endothelial cells are actively involved in atherosclerosis. The present study is, therefore, intended to investigate the diagnostic value of PDGF-β, as well as the factors affecting mortality in patients with acute myocardial infarction. According to the comparison of the study groups in terms of their PDGF-β levels, the NSTEMI group was found to have the highest level of PDGF-β. In the intergroup comparison of the subgroups of the patient group, the NSTEMI group was found to have significantly higher levels of PDGF-β than the STEMI group had (Post-Hoc test p=0.001). In the analyses of the values measured in the blood samples collected at the time of admission to the ED, PDGF-β was found to have a moderate positive linear relationship with WBC, troponin and lactate values. According to the analyses of the subgroups of the patient group, only in the NSTEMI group was there a moderate positive linear relationship between troponin and PDGF-β. We investigated whether serum PDGF-β is the new prognostic biomarker for AMI, serum PDGF-β levels were significantly higher, especially in patients with NSTEMI. However, in order for serum PDGF-β levels to be used as a marker for predicting prognosis, further comprehensive studies that focus on this subject are needed.