Abstract
Gallagher and Simmonds1 have shown that rats are protected against the lethal effects of carbon tetrachloride by prophylactic treatment with precursors of pyridine nucleotides. Such treatment was found also to protect against the loss of pyridine nucleotides from liver cells and to prevent necrosis of liver cells after dosing with carbon tetrachloride2,3. Rees, Spector and Sinha4 found that the administration of ‘Phenergan’ (10-(2-dimethylamino-isopropyl) phenothiazine hydrochloride) to animals poisoned with carbon tetrachloride protects the liver cells against necrosis. In the present investigation we examined the effect of treatment with ‘Phenergan’ on the pyridine nucleotides of liver cells in carbon tetrachloride poisoning. The work was also extended to other liver poisons such as thioacetamide and dimethyl nitrosamine.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call