Levels of Plasma Complement Split Products C3a desArg and C5a desArg and their Peripheral Blood Receptors are Elevated in Outpatient Adult Asthmatics with Decreased Asthma Control as Determined by the ACT and ATAQ Questionnaires

Abstract

RATIONALE: The recent NAEPP EPR-3 asthma guidelines emphasize the measurement of impairment from asthma and suggest the regular use of two validated questionnaires, the ACT (Asthma Control Test) and the ATAQ (Asthma Therapy Assessment Questionnaire) to determine the degree of control of asthma. As we have previously shown levels of the complement split product (CSP) plasma C5a desArg correlate with asthma quality of life scores (AQLQ, Juniper)(Charlot, 2005), we determined whether C5a desArg or C3a desArg and their peripheral blood receptor levels (CSPr) correlate with asthma control in adult asthmatics seen in an outpatient setting.