Abstract
：Objective To study thelevels of 2F5-like antibody recognized gp41 conserved epitope of HIV-1-infectedindividuals in China,explore the influence of 2F5-like antibody on disease progression ofHIV-1 infected individuals.Methods Direct ELISA was developed for the specific comparisonof levels of antibodies against gp41 and 4 (ELDKWA)-C peptides sera from HIV-1-infectedindividuals.Peripheral blood mononuclear cells(PBMC) were isolated from HIV-seronegativedonors.Multi-round PBMC neutralization assays were performed with HIV-1 isolate SF33.Thesupernatant p24-Ag of HIV was analyzed.Results Levels of 2F5-like antibodies in the slowprogressor (SP) plasma were significantly higher than those in typical progressor(TP)(P<0.05).There was significant correlation with the levels of 2F5 neutralizingantibody and gp41 antibodies(r=0.406,P<0.05).Conclusion The levels of 2F5-likeantibodies may influence on disease progression of HIV-infected individuals.The highlevels of neutralizing antibodies may arrest disease from progressing.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
