Abstract
Objectives:To explore levels of anti-oxidative molecules and inflammatory factors in patients with vascular dementia (VD) and their clinical significance.Methods:Sixty VD patients admitted in our hospital from January 2016 to January 2019 were classified into an experimental group, while another 60 healthy patients seeking physical examinations in the corresponding period were selected as a control group. Various indexes related to serum inflammatory factors and anti-oxidative molecules were compared among patients in such two groups. For the purpose of comparing anti-oxidative molecular expression levels and inflammatory factor levels in patients with VD of different severities, 60 cases in the experimental group were divided, based on a Mini-mental State Examination (MMSE) scale, into patients with mild symptoms (n=20, score: 21~26), patients with moderate symptoms (n=22, score: 10~20) and patients with severe symptoms (n=18, score: 0~9).Results:By contrast to the control group, levels of inflammatory factors (e.g., TNF-a, CRP and IL-6) in VD patients are all significantly increased and their differences show statistical significance (p<0.05); and, expression levels of anti-oxidative factors, including superoxide dismutase (SOD), glutathion peroxidase (GSH-Px), total antioxidant capacity (TAC), catalase (CAT) and glutathione reductase (GR), in the experimental group are apparently below those of the control group (P<0.05). As dementia degree increases, expression levels of serum anti-oxidative molecules in such patients are inclined to drop in a significant way (P<0.05), while inflammatory factor levels tend to go up gradually (P<0.05).Conclusions:If compared with the normal population, inflammatory factor levels in serum of VD patients are higher; however, expression levels of anti-oxidative molecules become below those of the normal population. Additionally, levels of inflammatory factors and anti-oxidative molecules may change obviously as severity of illness increases. This suggests that inflammation and oxidation play a certain role of auxoaction in VD patients.
Highlights
Vascular dementia is the most common complication in elderly patients with cerebrovascular ischemia and hemorrhagic cerebrovascular diseases.[1]
Sixty vascular dementia (VD) patients hospitalized in Baoding First Central Hospital from January 2016 to January 2019 were selected as the experimental group, while another 60 healthy cases seeking physical examinations in the corresponding period were adopted as the control group
As manifested in Tables-III and IV, an increase in dementia degree corresponds to a gradual rise of serum inflammatory factor levels; that is, levels of serum inflammatory factors are positively correlated with severity of illness
Summary
Vascular dementia is the most common complication in elderly patients with cerebrovascular ischemia and hemorrhagic cerebrovascular diseases.[1] Poor blood supply to the brain caused by vasculopathy can lead to brain hypoxia and a series of pathologic changes such as hypoperfusion and inflammatory responses. This may give rise to cognitive dysfunction of brain.[2] As pointed. It is indicated by comparison results that inflammatory factors and anti-oxidative molecules in VD patients are significantly different from those of the normal population Such differences may become increasingly apparent as the severity of illness increases. For details of the present study, they are described as follows
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