Levels and clinical significance of S100A8/A9 in serum of patients with lupus nephritis

Abstract

Objective To investigate level of S100A8/A9 in serum of patients with lupus nephritis(LN) and analyze the relation between S100A8/A9 and clinical parameters. Methods There were 50 female patients and 8 male patients with LN. Patients with LN (LN group) were divided into LN active group with more than 10 points(n=38)and LN inactive group with less than 10 points(n=20)by systemic lupus erythematosus disease activity index. Thirty healthy controls (control group) were individually matched for sex, age and body mass index. Serum levels of S100A8/A9 of LN patients were detected by enzyme-linked immunosorbent assay, the clinical data of LN patients were collected. Results ①Serum level of S100A8/A9 was significantly higher in LN group than those of control group (P 0.05). ③Serum level of S100A8/A9 was positively correlated with anti-dsDNA, C-reactive protein, serum creatinine, 24-hour urine protein and SLEDAI scores(r=0.27, P=0.04; r=0.4, P=0.002; r=0.38, P=0.003; r=0.30, P=0.02; r=0.90, P=0.000). Serum level of S100A8/A9 was negatively correlated with complement C3, C4 and creatinine clearance(r=-0.28, P=0.036; r=-0.38, P=0.036; r=-0.322, P=0.014). There was no correlation between serum level of S100A8/A9 and erythrocyte sedimentation rate (r=0.098, P=0.464). Conclusions S100A8/A9 may be involved in the occurrence and development of lupus nephritis. Dynamic observation of serum S100A8/A9 level contributes to monitor LN activity, evaluates the severity of kidney damage, which has clinical significances for treatment options, efficacy evaluation in LN patients in a way. Key words: Lupus Nephritis; S100 Proteins